A Seventh-day Adventist Organization

Basic Sciences

Center for Dental Research

Treating Periodontal Disease with iPS cell-derived Mesenchymal Stem Cells in a Rat Model

Periodontal disease, a prevalent worldwide disease, is characterized by the destruction of periodontal supporting tissues, including gingiva, cementum, periodontal ligament (PDL) and alveolar bone. Current therapeutic approaches for periodontal disease such as scaling, root planning, and implantation of biomaterials only lead to variable and unpredictable clinical results. There is a lack of effective therapy that can regenerate the periodontium damaged by periodontitis.

The long-term goal is to utilize induced pluripotent stem cells (iPSCs), derived mesenchymal stem cells (MSCs), that are engineered with therapeutic genes to regenerate periodontium. The objective of this project was to develop a rat model that can mimic clinical periodontitis and investigate a new model of using iPSC-MSCs to treat periodontitis and regenerate periodontium. Preliminary results suggest that the engineered iPSC-MSCs are capable of providing certain unique therapeutic effects, which help control periodontitis.